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Mutations associated with Alzheimer's disease and aged serum synergistically elicit blood-brain barrier dysfunction in a tissue-engineered model.

Fluids and barriers of the CNS - 16 Feb 2026

Chung Tracy D, Liang Lily, Wang Linus, Kim Elizabeth G, Gupta Sukriti, Pandey Ikshu, Searson Peter C

Abstract excerpt

BACKGROUND: Alzheimer’s disease is heterogeneous with a wide range of etiological subtypes derived from multiple risk factors. Many of these risk factors are either directly or indirectly related to stresses that act on the blood-bran barrier. Deconvoluting the influence of these stresses on blood-brain barrier function is important in understanding disease mechanisms and subtypes. METHODS: We used a...

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Aging
Amyloid beta-Protein Precursor
Blood-Brain Barrier
Endothelial Cells
Microvessels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tissue Engineering

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PMID: 41699702
DOI: 10.1186/s12987-026-00773-x
PMCID: PMC13011675

Genes

APP
PSEN1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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