Article

Interrogating the structure and function of the human voltage-gated proton channel (hHv1) with a fluorescent noncanonical amino acid

2025-10-24

Abstract excerpt

The human voltage-gated proton channel (hH v 1) is a dimer of voltage-sensor domains (VSDs) containing highly selective proton permeation pathways in each monomer. In addition to voltage, hH v 1 is regulated by other stimuli, including pH gradients, mechanical forces, and ligands such as Zn 2+ . Aside from the VSDs, this membrane protein contains an N-terminal domain and a C-terminal coiled-coil domain (CC) for...

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Literature Corpus work: c56c4cf3-5618-5992-a0fd-3810b9600bea
DOI: 10.1101/2025.10.23.684235

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