Article

Regulation of the human voltage-gated proton channel by membrane sterols

2026-08-22

Abstract excerpt

Cholesterol is a key component of eukaryotic cell membranes, promoting membrane stability and modulating the function of many membrane proteins, including ion channels. In our previous work using purified human voltage-gated proton channel proteins, we showed that cholesterol inhibits the hHv1 channel by altering the conformational dynamics of its S4 segment, the key element that senses membrane voltage to control...

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Literature Corpus work: 4b3ff995-db3b-57e6-9235-b4c8341118e4
DOI: 10.64898/2026.08.20.746042

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