Article

NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation

2026-07-01

Abstract excerpt

<h4>Summary</h4> Aberrant epigenetic reprogramming together with dysregulated mTOR signaling are hallmarks of cancer, where altered chromatin methylation and nutrient-sensing pathways cooperate to drive tumor progression. S -adenosylmethionine (SAM), the universal methyl donor, is essential for these processes, yet how tumors sustain elevated SAM availability to support oncogenic transmethylation reactions remai...

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Literature Corpus work: c5578ae3-394c-50b7-b9af-0a3b86916445
DOI: 10.64898/2026.06.30.734970

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