Back to search

Article

PHGDH is a targetable driver of PDAC progression

2026-03-14

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) arises in a nutrient-deprived microenvironment through progressive stages from pancreatic intraepithelial neoplasia (PanIN) to invasive carcinoma. While serine metabolism supports tumor growth across multiple cancer types, the stage-specific role of de novo serine synthesis in PDAC evolution remains undefined. Here, we show that expression of phosphoglycerate dehydrogenase (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
329c917e-ea2e-5d6f-9085-4f1a160f2bd8
DOI
10.64898/2026.03.11.711147
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
PHGDH is a targetable driver of PDAC progressionDOI 10.64898/2026.03.11.711147
Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1Semantic proximity
Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN ‐amplified neuroblastomaSemantic proximity
Metabolic Reprogramming Is an Initial Step in Pancreatic Carcinogenesis That Can Be Targeted to Inhibit Acinar-to-Ductal MetaplasiaSemantic proximity
Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.Semantic proximity
The complex landscape of pancreatic cancer metabolismSemantic proximity
Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolismSemantic proximity
KRAS: feeding pancreatic cancer proliferation.Semantic proximity
Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma.Semantic proximity
PHGDH supports liver ceramide synthesis and sustains lipid homeostasisSemantic proximity
The biological role of metabolic reprogramming in pancreatic cancerSemantic proximity
MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastomaSemantic proximity
ISL2 is an epigenetically silenced tumor suppressor and regulator of metabolism in pancreatic cancerSemantic proximity
Select a neighboring publication to make it the new centre.