Article

NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancer

2025-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD+ salvage pathway and a promising therapeutic target in cancer. Resistance to NAMPT inhibitors, such as FK866, remains a key limitation to their clinical translation. While acquired resistance in cancer cell lines has been linked to target mutations, increased drug efflux and metabolic reprogramming, innate resi...

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Literature Corpus work: 7d7c6aa3-e597-5142-a6a7-beb123fa47d0
DOI: 10.1101/2025.04.29.651153

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NNMT drives innate sensitivity to NAMPT inhibition in YAP-dependent stem-like/ mesenchymal prostate cancerDOI 10.1101/2025.04.29.651153Read

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