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Article

PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma

22 Aug 2019

Abstract excerpt

Pediatric high-grade gliomas are among the deadliest of childhood cancers due to limited knowledge of early driving events in their gliomagenesis and the lack of effective therapies available. In this study, we investigate the oncogenic role of PPM1D, a protein phosphatase often found truncated in pediatric gliomas such as DIPG, and uncover a synthetic lethal interaction between PPM1D mutations and nicotinamide...

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PMID: 31439867
DOI: 10.1038/s41467-019-11732-6

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PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in gliomaPMID 31439867Read ↗

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