SHMT2 promotes thyroid cancer metastasis through epigenetic activation of AKT signaling

Abstract excerpt

<title>Abstract</title> <p>Cancer cells alter their metabolism and epigenetics to support cancer progression. However, the key modulator connecting metabolism and epigenetics is still limited. Here, we reveal that SHMT2 generates SAM to epigenetically repress PTEN, leading to thyroid cancer metastasis depending on activation of AKT signaling. SHMT2 is elevated in thyroid cancer, which cooperates with poor prognos...

Topics

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• Cancer, Hypoxia, and Metabolism
• Carbon
• Folate and B Vitamins Research
• Multiomics
• Mutation
• Neuroblastoma Research and Treatments
• Phenotype
• Proto-Oncogene Proteins B-raf

Identifiers and source

Literature Corpus work

704ae1d7-8333-5645-a03f-1c8c780be74f

DOI

10.21203/rs.3.rs-3254791/v1