Article

Cyclocreatine suppresses prostate tumorigenesis through dual effects on SAM and creatine metabolism

2021-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Prostate cancer is highly prevalent, being the second most common cause of cancer mortality in men worldwide. Applying a novel genetically engineered mouse model (GEMM) of aggressive prostate cancer driven by deficiency of PTEN and SPRY2 (Sprouty 2) tumour suppressors, we identified enhanced creatine metabolism within the phosphagen system in progressive disease. Altered creatine metabolism was...

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Literature Corpus work: b36e5b6b-ce06-5ff8-8b4c-2ebe98f519e6
DOI: 10.1101/2021.02.26.432994

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