NNMT-driven metabolic reprogramming creates a NAMPT druggable vulnerability and reveals liquid biopsy biomarkers for TKI resistance in EGFR-mutant NSCLC.

doi:10.1016/j.canlet.2025.218032

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Article

NNMT-driven metabolic reprogramming creates a NAMPT druggable vulnerability and reveals liquid biopsy biomarkers for TKI resistance in EGFR-mutant NSCLC.

Cancer letters - 28 Nov 2025

Pulido I, García-Cañaveras J C, Rodríguez M L, Becker J H, López A, Aupí M, Aparisi S, Chuliá-Peris L, Tamayo-Torres E, Carreres-Rey C, Alcácer Fernández-Coronado J, Benet M, Montero S, Mena S, Sandoval J, Pereda J, Alcácer J, Calabuig-Fariñas S, Jantus-Lewintre E, Cremades A, Galbis-Caravajal J M, Martín-Martorell P, Insa A, Massad Malek G, Juan-Vidal O, Lahoz A, Shimamura T, Carretero J

Abstract excerpt

Lung cancer is the deadliest neoplasia worldwide. Despite the availability of targeted therapies like tyrosine kinase inhibitors (TKIs) for EGFR-driven tumours in Non-Small Cell Lung Cancer (NSCLC), drug resistance remains a major factor that dramatically cuts life expectancy. Here we identify how increased expression of nicotinamide N-methyltransferase (NNMT) in TKI-resistant cancer cells diverts nicotinamide to...

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Identifiers

PMID: 40935282
DOI: 10.1016/j.canlet.2025.218032

Genes

EGFR
NAMPT
NNMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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