Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.

doi:10.1053/j.gastro.2021.06.045

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Article

Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression.

Gastroenterology - 1 Nov 2021

Hu Tuo, Shukla Surendra K, Vernucci Enza, He Chunbo, Wang Dezhen, King Ryan J, Jha Kanupriya, Siddhanta Kasturi, Mullen Nicholas J, Attri Kuldeep S, Murthy Divya, Chaika Nina V, Thakur Ravi, Mulder Scott E, Pacheco Camila G, Fu Xiao, High Robin R, Yu Fang, Lazenby Audrey, Steegborn Clemens, Lan Ping, Mehla Kamiya, Rotili Dante, Chaudhary Sarika, Valente Sergio, Tafani Marco, Mai Antonello, Auwerx Johan, Verdin Eric, Tuveson David, Singh Pankaj K

Abstract excerpt

BACKGROUND & AIMS: SIRT5 plays pleiotropic roles via post-translational modifications, serving as a tumor suppressor, or an oncogene, in different tumors. However, the role SIRT5 plays in the initiation and progression of pancreatic ductal adenocarcinoma (PDAC) remains unknown. METHODS: Published datasets and tissue arrays with SIRT5 staining were used to investigate the clinical relevance of SIRT5 in PDAC....

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Identifiers

PMID: 34245764
DOI: 10.1053/j.gastro.2021.06.045
PMCID: PMC8546779

Genes

SIRT5
GOT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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