Article

ZNF423 orthologs are highly constrained in vertebrates but show domain-level plasticity across invertebrate lineages

2020-03-11

Abstract excerpt

ZNF423 encodes 30 C2H2 zinc fingers that bind DNA and a variety of lineage- and signal-dependent transcription factors. ZNF423 genetic variants are proposed to cause neurodevelopmental and ciliopathy-related disorders in humans. Mouse models show midline brain defects, including cerebellar vermis hypoplasia, and defects in adipogenesis. Here I show strong protein sequence constraint among 165 vertebrate orthologs...

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Literature Corpus work: 43592e35-43f7-5157-9b4b-6e14c6f56f81
DOI: 10.1101/2020.03.09.984518

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