Article

Smoking Interaction with a Polygenic Risk Score for Reduced Lung Function

2021-03-29

Abstract excerpt

<h4>Importance</h4> Risk to airflow limitation and Chronic Obstructive Pulmonary Disease (COPD) is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains unclear whether gene-by-smoking interactions contribute to quantitative measures of lung function. <h4>Objective</h4> Determine whether smoking modifies the effect of a polygenic risk score’s (PRS’s) association with reduced lu...

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Literature Corpus work: c515fcbc-8e73-594f-a697-303bba5b6f7d
DOI: 10.1101/2021.03.26.21254415

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