Article
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.
International journal of epidemiology - 1 Jun 2017
Aschard Hugues, Tobin Martin D, Hancock Dana B, Skurnik David, Sood Akshay, James Alan, Vernon Smith Albert, Manichaikul Ani W, Campbell Archie, Prins Bram P, Hayward Caroline, Loth Daan W, Porteous David J, Strachan David P, Zeggini Eleftheria, O'Connor George T, Brusselle Guy G, Boezen H Marike, Schulz Holger, Deary Ian J, Hall Ian P, Rudan Igor, Kaprio Jaakko, Wilson James F, Wilk Jemma B, Huffman Jennifer E, Hua Zhao Jing, de Jong Kim, Lyytikäinen Leo-Pekka, Wain Louise V, Jarvelin Marjo-Riitta, Kähönen Mika, Fornage Myriam, Polasek Ozren, Cassano Patricia A, Barr R Graham, Rawal Rajesh, Harris Sarah E, Gharib Sina A, Enroth Stefan, Heckbert Susan R, Lehtimäki Terho, Gyllensten Ulf, Jackson Victoria E, Gudnason Vilmundur, Tang Wenbo, Dupuis Josée, Soler Artigas María, Joshi Amit D, London Stephanie J, Kraft Peter
Abstract excerpt
Background: Smoking is the strongest environmental risk factor for reduced pulmonary function. The genetic component of various pulmonary traits has also been demonstrated, and at least 26 loci have been reproducibly associated with either FEV 1 (forced expiratory volume in 1 second) or FEV 1 /FVC (FEV 1 /forced vital capacity). Although the main effects of smoking and genetic loci are well established, the...
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