Article
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts.
The Lancet. Respiratory medicine - 1 Jul 2020
Moll Matthew, Sakornsakolpat Phuwanat, Shrine Nick, Hobbs Brian D, DeMeo Dawn L, John Catherine, Guyatt Anna L, McGeachie Michael J, Gharib Sina A, Obeidat Ma'en, Lahousse Lies, Wijnant Sara R A, Brusselle Guy, Meyers Deborah A, Bleecker Eugene R, Li Xingnan, Tal-Singer Ruth, Manichaikul Ani, Rich Stephen S, Won Sungho, Kim Woo Jin, Do Ah Ra, Washko George R, Barr R Graham, Psaty Bruce M, Bartz Traci M, Hansel Nadia N, Barnes Kathleen, Hokanson John E, Crapo James D, Lynch David, Bakke Per, Gulsvik Amund, Hall Ian P, Wain Louise, Weiss Scott T, Silverman Edwin K, Dudbridge Frank, Tobin Martin D, Cho Michael H
Abstract excerpt
BACKGROUND: Genetic factors influence chronic obstructive pulmonary disease (COPD) risk, but the individual variants that have been identified have small effects. We hypothesised that a polygenic risk score using additional variants would predict COPD and associated phenotypes. METHODS: We constructed a polygenic risk score using a genome-wide association study of lung function (FEV1 and FEV1/forced vital...
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