Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.

doi:10.1016/j.ebiom.2024.105234

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Article

Polygenic inheritance and its interplay with smoking history in predicting lung cancer diagnosis: a French-Canadian case-control cohort.

EBioMedicine - 1 Aug 2024

Boumtje Véronique, Manikpurage Hasanga D, Li Zhonglin, Gaudreault Nathalie, Armero Victoria Saavedra, Boudreau Dominique K, Renaut Sébastien, Henry Cyndi, Racine Christine, Eslami Aida, Bougeard Stéphanie, Vigneau Evelyne, Morissette Mathieu, Arsenault Benoit J, Labbé Catherine, Laliberté Anne-Sophie, Martel Simon, Maltais François, Couture Christian, Desmeules Patrice, Mathieu Patrick, Thériault Sébastien, Joubert Philippe, Bossé Yohan

Abstract excerpt

BACKGROUND: The most near-term clinical application of genome-wide association studies in lung cancer is a polygenic risk score (PRS). METHODS: A case-control dataset was generated consisting of 4002 lung cancer cases from the LORD project and 20,010 ethnically matched controls from CARTaGENE. A genome-wide PRS including >1.1 million genetic variants was derived and validated in UK Biobank (n = 5419 lung cancer...

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PMID: 38970920
DOI: 10.1016/j.ebiom.2024.105234
PMCID: PMC11282926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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