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Article

Genome-Wide Gene-by-Smoking Interaction Study of Chronic Obstructive Pulmonary Disease.

American journal of epidemiology - 4 May 2021

Kim Woori, Prokopenko Dmitry, Sakornsakolpat Phuwanat, Hobbs Brian D, Lutz Sharon M, Hokanson John E, Wain Louise V, Melbourne Carl A, Shrine Nick, Tobin Martin D, Silverman Edwin K, Cho Michael H, Beaty Terri H

Abstract excerpt

Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette smoking and genetic susceptibility, but little is known about gene-by-smoking interactions. We performed a genome-wide association analysis of 179,689 controls and 21,077 COPD cases from UK Biobank subjects of European ancestry recruited from 2006 to 2010, considering genetic main effects and gene-by-smoking interaction effects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33106845
DOI: 10.1093/aje/kwaa227
PMCID: PMC8096488

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