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Article

Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function.

JAMA network open - 1 Dec 2021

Kim Woori, Moll Matthew, Qiao Dandi, Hobbs Brian D, Shrine Nick, Sakornsakolpat Phuwanat, Tobin Martin D, Dudbridge Frank, Wain Louise V, Ladd-Acosta Christine, Chatterjee Nilanjan, Silverman Edwin K, Cho Michael H, Beaty Terri H

Abstract excerpt

Importance: The risk of airflow limitation and chronic obstructive pulmonary disease (COPD) is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains unclear whether gene-by-smoking interactions are associated with quantitative measures of lung function. Objective: To assess the interaction of cigarette smoking and polygenic risk score in association with reduced lung function....

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Source

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Identifiers

PMID: 34913977
DOI: 10.1001/jamanetworkopen.2021.39525
PMCID: PMC8678715

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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