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Exploring the genetics of airflow limitation in lung function across the lifespan – a polygenic risk score study

12 Aug 2024

Abstract excerpt

Background Chronic obstructive pulmonary disease (COPD) is caused by interactions between many factors across the life course, including genetics. A proportion of COPD may be due to reduced lung growth in childhood. We hypothesized that a polygenic risk score (PRS) for COPD is associated with lower lung function already in childhood and up to adulthood. Methods A weighted PRS was calculated based on the 82...

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PMID: 39568778
DOI: 10.1016/j.eclinm.2024.102731

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