Article

Inhibition of lagging strand replication by G-rich telomeric DNA and the shelterin subunit POT1

2025-11-14

Abstract excerpt

<h4>ABSTRACT</h4> Telomeres preserve stable eukaryotic chromosomes by protecting the natural chromosome ends from DNA repair but pose a persistent challenge to the replication machinery and an endogenous source of replication stress. Different features have been implicated in causing this effect but how the canonical replication process is altered at telomeres in mechanistic terms remains poorly understood. To ad...

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Literature Corpus work: c4fa8063-3e36-573b-b51b-06bd1a5f8cdf
DOI: 10.1101/2025.11.13.688213

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