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The human telomeric proteome during telomere replication

13 Oct 2021

Abstract excerpt

Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of the semi-conservative DNA replication machinery to replicate the bulk of telomeric DNA repeats. To investigate telomere replication in a comprehensive manner, we...

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PMID: 34747482
DOI: 10.1093/nar/gkab1015

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