Article

POT1 recruits and regulates CST–Polα/Primase at human telomeres

2023-05-09

Abstract excerpt

<h4>Summary</h4> Telomere maintenance requires extension of the G-rich telomeric repeat strand by telomerase and fill-in synthesis of the C-rich strand by Polα/Primase. Telomeric Polα/Primase is bound to Ctc1-Stn1-Ten1 (CST), a single-stranded DNA-binding complex. Like mutations in telomerase, mutations affecting CST–Polα/Primase result in pathological telomere shortening and cause a telomere biology disorder, Co...

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Literature Corpus work: 5413d11e-3232-51a3-8a92-7d2e37c1ffd5
DOI: 10.1101/2023.05.08.539880

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