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Article

TRF2 promotes dynamic and stepwise looping of POT1 bound telomeric overhang

18 Nov 2021

Abstract excerpt

Human telomeres are protected by shelterin proteins, but how telomeres maintain a dynamic structure remains elusive. Here, we report an unexpected activity of POT1 in imparting conformational dynamics of the telomere overhang, even at a monomer level. Strikingly, such POT1-induced overhang dynamics is greatly enhanced when TRF2 engages with the telomere duplex. Interestingly, TRF2, but not TRF2ΔB, recruits...

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PMID: 34850123
DOI: 10.1093/nar/gkab1123

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