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Article

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation

5 Jul 2019

Abstract excerpt

In cortical regions of brains from individuals with preclinical or clinical Alzheimer's disease (AD), extracellular β-amyloid (Aβ) deposition precedes the aggregation of pathological intracellular tau (the product of the gene microtubule-associated protein tau (MAPT)). To our knowledge, current mouse models of tauopathy reconstitute tau pathology by overexpressing mutant human tau protein. Here, through a...

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PMID: 31273083
DOI: 10.1074/jbc.ra119.009487

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