Age- and amyloid-β-dependent initiation of neurofibrillary tau tangles: NLFTau ^m/h , an improved mouse model of Alzheimer’s disease without mutations in <i>MAPT</i>

Abstract excerpt

<h4>ABSTRACT</h4> The lack of models in which ageing and amyloid-β (Aβ) initiate neurofibrillary tau tangles, independent of MAPT mutations, limits mechanistic insights into Alzheimer’s disease. Here, we characterise NLFTau m/h , a novel mouse model that recapitulates the gradual transition from Aβ accumulation to tau pathology by 24 months. We show that combined effects of ageing, Aβ, and human tau expression...

Topics

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• Alzheimer Disease
• Alzheimer's disease research and treatments
• Amyloid beta-Protein Precursor
• Disease Models, Animal
• Mice, Inbred C57BL
• Mice, Transgenic
• Presenilin-1
• tau Proteins

Identifiers and source

Literature Corpus work

1107a584-b14c-5c0a-8c93-f7903217cd26

DOI

10.1101/2024.11.04.621900