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Lessons from Tau-Deficient Mice

1 Jan 2012

Abstract excerpt

Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to the umbrella term "tauopathies" for these conditions, also emphasizing the central role of tau in AD and FTD. Generation of transgenic mouse models expressing human tau in the brain has...

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PMID: 22720190
DOI: 10.1155/2012/873270

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