Article

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds

2023-05-30

Abstract excerpt

<title>Abstract</title> Tau pathology is a hallmark feature of several neurodegenerative diseases including frontotemporal dementia (FTD) spectrum and Alzheimer’s disease. The accumulation of pathological tau is linked to cognitive impairment. However, the sequence of events and the form of tau that confers toxicity are still unclear, due to the lack of physiological models of tauopathy initiation and progress...

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Literature Corpus work: 3efc4fde-4cf3-5a6a-b61f-e3821936fbe7
DOI: 10.21203/rs.3.rs-2992966/v1

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