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Article

Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

Neurobiology of aging - 1 Dec 2003

Oddo Salvatore, Caccamo Antonella, Kitazawa Masashi, Tseng Bertrand P, LaFerla Frank M

Abstract excerpt

Amyloid-beta (Abeta) containing plaques and tau-laden neurofibrillary tangles are the defining neuropathological features of Alzheimer's disease (AD). To better mimic this neuropathology, we generated a novel triple transgenic model of AD (3xTg-AD) harboring three mutant genes: beta-amyloid precursor protein (betaAPPSwe), presenilin-1 (PS1M146V), and tauP301L. The 3xTg-AD mice progressively develop Abeta and tau...

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Identifiers

PMID: 14643377
DOI: 10.1016/j.neurobiolaging.2003.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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