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Article

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

29 Sept 2023

Abstract excerpt

Tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. Recently, a human tau knock-in (MAPT KI) mouse was developed that may overcome many limitations associated with current animal models used to study tau. In MAPT KI mice, the entire murine Mapt gene was replaced with the human MAPT gene under control of the endogenous Mapt promoter. This model...

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PMID: 37842124
DOI: 10.3389/fnagi.2023.1265151

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