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Article

Haplotype-Specific Expression Analysis of MHC Class II Genes in Healthy Individuals and Rheumatoid Arthritis Patients.

Frontiers in immunology - 1 Jan 2021

Houtman Miranda, Hesselberg Espen, Rönnblom Lars, Klareskog Lars, Malmström Vivianne, Padyukov Leonid

Abstract excerpt

HLA-DRB1 alleles have been associated with several autoimmune diseases. For anti-citrullinated protein antibody positive rheumatoid arthritis (RA), HLA-DRB1 shared epitope (SE) alleles are the major genetic risk factors. In order to study the genetic regulation of major histocompatibility complex (MHC) Class II gene expression in immune cells, we investigated transcriptomic profiles of a variety of immune cells...

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Topics

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Share to Alleles
Share to Arthritis, Rheumatoid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Haplotypes

Share to HLA-DQ Antigens

Share to HLA-DRB1 Chains

Source

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Identifiers

PMID: 34484204
DOI: 10.3389/fimmu.2021.707217
PMCID: PMC8416041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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