Article
Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity.
Scientific reports - 7 Jul 2016
Nagafuchi Yasuo, Shoda Hirofumi, Sumitomo Shuji, Nakachi Shinichiro, Kato Rika, Tsuchida Yumi, Tsuchiya Haruka, Sakurai Keiichi, Hanata Norio, Tateishi Shoko, Kanda Hiroko, Ishigaki Kazuyoshi, Okada Yukinori, Suzuki Akari, Kochi Yuta, Fujio Keishi, Yamamoto Kazuhiko
Abstract excerpt
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that leads to destructive arthritis. Although the HLA class II locus is the strongest genetic risk factor for rheumatoid arthritis, the relationship between HLA class II alleles and lymphocyte activation remains unclear. We performed immunophenotyping of peripheral blood mononuclear cells on 91 HLA-DRB1-genotyped RA patients and 110 healthy...
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