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Antigen Presentation-Independent Reciprocal Immune Modulation by <i>HLA-DRB1</i> Allelic Epitopes that Associate with Autoimmune Disease Risk or Protection

2020-08-25

Abstract excerpt

Statistical associations between particular human leukocyte antigen (HLA) alleles and susceptibility to - or protection from - autoimmune diseases have been long observed. Allele-specific antigen presentation (AP) has been widely proposed as a culprit mechanism; however, direct evidence to substantiate that hypothesis is scant. Here we demonstrate AP-independent differential macrophage activation by HLA-DRB1 alle...

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Literature Corpus work
233d4c87-81e2-5ac6-981a-a1ba39002490
DOI
10.1101/2020.08.25.265348
Open publication

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Antigen Presentation-Independent Reciprocal Immune Modulation by <i>HLA-DRB1</i> Allelic Epitopes that Associate with Autoimmune Disease Risk or ProtectionDOI 10.1101/2020.08.25.265348
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