Article
Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.
Acta neuropathologica - 1 Feb 2022
Spiteri Alanna G, Wishart Claire L, Pamphlett Roger, Locatelli Giuseppe, King Nicholas J C
Abstract excerpt
In neurological diseases, the actions of microglia, the resident myeloid cells of the CNS parenchyma, may diverge from, or intersect with, those of recruited monocytes to drive immune-mediated pathology. However, defining the precise roles of each cell type has historically been impeded by the lack of discriminating markers and experimental systems capable of accurately identifying them. Our ability to...
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