Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degeneration

12 Dec 2022

Abstract excerpt

BACKGROUND: Both resident microglia and invading peripheral immune cells can respond to injury and degeneration in the central nervous system. However, after dead and dying neurons have been cleared and homeostasis is re-established, it is unknown whether resident immune cells fully resume normal functions and to what degree the peripheral immune cells take up residence. METHODS: mouse model of inducible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36510226
DOI: 10.1186/s12974-022-02652-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional distinctions of co-resident microglia and monocyte-derived macrophages after retinal degenerationPMID 36510226Read ↗

Molecular profiling of resident and infiltrating mononuclear phagocytes during rapid adult retinal degeneration using single-cell RNA sequencingSemantic proximity Read ↗

Infiltrating monocytes augment alternative complement activation and exacerbate inherited retinal degeneration in a mouse modelSemantic proximity Read ↗

Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retinaSemantic proximity Read ↗

Microglia Regulate Neuroglia Remodeling in Various Ocular and Retinal InjuriesSemantic proximity Read ↗

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 InteractionsSemantic proximity Read ↗

Myeloid masquerade: Microglial transcriptional signatures in retinal development and diseaseSemantic proximity Read ↗

Fate mapping of peripherally derived macrophages reveals a long-lasting engrafted population that maintains a distinct transcriptomic profile for up to 8 months after Traumatic Brain InjurySemantic proximity Read ↗

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function.Semantic proximity Read ↗

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal modelSemantic proximity Read ↗

Epigenetic Adaptation Drives Monocyte Differentiation into Microglia-Like Cells Upon Engraftment into the Central Nervous SystemSemantic proximity Read ↗

More than meets the eye: The role of microglia in healthy and diseased retinaSemantic proximity Read ↗

CCR1 Mediates Müller Cell Activation and Photoreceptor Cell Death in Macular and Retinal DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.