Article

Alzheimer’s disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model

2024-01-25

Abstract excerpt

<h4>SUMMARY</h4> The strongest risk factors for Alzheimer’s disease (AD) include the χ4 allele of apolipoprotein E (APOE), the R47H variant of triggering receptor expressed on myeloid cells 2 (TREM2), and female sex. Here, we combine APOE4 and TREM2R47H ( R47H ) in female P301S tauopathy mice to identify the pathways activated when AD risk is the strongest, thereby highlighting disease-causing mechanisms. We...

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Literature Corpus work: 9a332ca6-351f-5f1a-a226-de42392f8c09
DOI: 10.1101/2024.01.24.577107

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