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Sex-dependent interferon signaling drives female-biased vulnerability in Alzheimer’s disease

2025-08-28

Abstract excerpt

Alzheimer’s disease (AD) disproportionately affects women, yet the neurobiological mechanisms underlying this sex bias remain poorly understood. Here, we identify a sex-dependent activation of type I interferon (IFN-I) signaling as a contributor to this disparity. Transcriptomic profiling of brain from AD patients revealed selective enrichment of IFN-I pathway in females. This immune signature was mirrored in the...

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Identifiers and source

Literature Corpus work
639637a6-6136-52dc-9846-567973d80b59
DOI
10.1101/2025.08.22.671724
Open publication

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Sex-dependent interferon signaling drives female-biased vulnerability in Alzheimer’s diseaseDOI 10.1101/2025.08.22.671724
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