Article

Copy Number Variation at 16p11.2 Imparts Transcriptional Alterations in Neural Development in an hiPSC-derived Model of Corticogenesis

2020-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Microdeletions and microduplications of the 16p11.2 chromosomal locus are associated with syndromic neurodevelopmental disorders and reciprocal physiological conditions such as macro/microcephaly and high/low body mass index. To facilitate cellular and molecular investigations of these phenotypes, 65 clones of human induced pluripotent stem cells (hiPSCs) were generated from 13 individuals with...

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Literature Corpus work: 2402fa2a-62d8-5776-99c6-008027db16fd
DOI: 10.1101/2020.04.22.055731

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