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Article

<i>ZC4H2</i> loss of function is associated with temporal dysregulation of neural stem proliferation and neuron development

2026-01-15

Abstract excerpt

ZC4H2 is an X-linked zinc finger transcription factor essential for early neurodevelopment. Pathogenic variants in ZC4H2 are associated with both central and peripheral nervous system pathologies. The molecular and cellular mechanisms driving these phenotypes remain poorly understood, particularly in human female models that have undergone X chromosome inactivation. Neuronal models were differentiated from a huma...

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Literature Corpus work
38708b7a-f72c-52da-987e-680e794ab367
DOI
10.64898/2026.01.15.699794
Open publication

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