Article

Altered chromatin occupancy of patient-associated H4 mutants misregulate neuronal differentiation

2023-09-29

Abstract excerpt

<h4>Summary</h4> Chromatin is a crucial regulator of gene expression and tightly controls development across species. Mutations in only one copy of multiple histone genes were identified in children with developmental disorders characterized by microcephaly, but their mechanistic roles in development remain unclear. Here we focus on dominant mutations affecting histone H4 lysine 91. These H4K91 mutants form aberr...

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Literature Corpus work: b1ea3fc3-c0f7-5f04-8fdb-593bdaefb6f2
DOI: 10.1101/2023.09.29.560141

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