The CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1

Abstract excerpt

Circadian rhythms are generated by a transcription-translation feedback loop that establishes cell-autonomous biological timing of ~24-hours. A prevalent human variation in the core clock gene cryptochrome 1, Cry1Δ11, lengthens circadian period to cause Delayed Sleep Phase Disorder (DSPD). CRY1 has a 55 kDa photolyase homology region (PHR) followed by a ~100 residue tail that is intrinsically disordered; the Δ11 v...

Topics

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• ARNTL Transcription Factors
• Circadian Clocks
• CLOCK Proteins
• Cryptochromes
• Crystallography, X-Ray
• Protein Domains
• Sf9 Cells
• Spodoptera

Identifiers and source

Literature Corpus work

c3ea78b0-fc69-5598-8049-e0a9b18d7b1b

DOI

10.1101/758714