Article

DHHC3-dependent S-Acylation of CRY1 regulates its subcellular localization and repressor function in the circadian clock

2026-05-22

Abstract excerpt

The circadian clock is essential for maintaining cellular homeostasis and physiological fitness. At the molecular level, core clock proteins function via transcriptional-translational feedback loops in the cellular oscillator, and are highly regulated by post-translational modifications. Our unbiased screening of core clock proteins revealed that Cryptochrome 1 (CRY1), the central transcriptional repressor in the...

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Literature Corpus work: d5f0b943-6e6a-5c5d-b04e-01f75c039b05
DOI: 10.64898/2026.05.20.726662

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