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Article

Knockout-Rescue Embryonic Stem Cell-Derived Mouse Reveals Circadian-Period Control by Quality and Quantity of CRY1.

Molecular cell - 5 Jan 2017

Ode Koji L, Ukai Hideki, Susaki Etsuo A, Narumi Ryohei, Matsumoto Katsuhiko, Hara Junko, Koide Naoshi, Abe Takaya, Kanemaki Masato T, Kiyonari Hiroshi, Ueda Hiroki R

Abstract excerpt

To conduct comprehensive characterization of molecular properties in organisms, we established an efficient method to produce knockout (KO)-rescue mice within a single generation. We applied this method to produce 20 strains of almost completely embryonic stem cell (ESC)-derived mice ("ES mice") rescued with wild-type and mutant Cry1 gene under a Cry1-/-:Cry2-/- background. A series of both...

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Source

Identifiers

PMID: 28017587
DOI: 10.1016/j.molcel.2016.11.022

Genes

CRY1
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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