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Article

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2017

Michael Alicia K, Fribourgh Jennifer L, Chelliah Yogarany, Sandate Colby R, Hura Greg L, Schneidman-Duhovny Dina, Tripathi Sarvind M, Takahashi Joseph S, Partch Carrie L

Abstract excerpt

The basic helix-loop-helix PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle Arnt-like protein 1) sits at the core of the mammalian circadian transcription/translation feedback loop. Precise control of CLOCK:BMAL1 activity by coactivators and repressors establishes the ∼24-h periodicity of gene expression. Formation of a repressive complex, defined by the core clock proteins cryptochrome 1...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28143926
DOI: 10.1073/pnas.1615310114
PMCID: PMC5321004

Genes

CLOCK
CRY1
BMAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.PMID 28143926Read ↗

The CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1Semantic proximity Read ↗

The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm.Semantic proximity Read ↗

Biochemical mechanism of the mammalian circadian clockSemantic proximity Read ↗

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.Semantic proximity Read ↗

Cryptochrome-Timeless structure reveals circadian clock timing mechanismsSemantic proximity Read ↗

Intermolecular recognition revealed by the complex structure of human CLOCK-BMAL1 basic helix-loop-helix domains with E-box DNA.Semantic proximity Read ↗

Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock.Semantic proximity Read ↗

Mammalian Period represses and de-represses transcription by displacing CLOCK-BMAL1 from promoters in a Cryptochrome-dependent manner.Semantic proximity Read ↗

Biochemical analysis of the canonical model for the mammalian circadian clock.Semantic proximity Read ↗

Structure function analysis of mammalian cryptochromes.Semantic proximity Read ↗

Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulatorSemantic proximity Read ↗

Dynamic regulation of the serine loop by distant mutations reveals allostery in cryptochrome1.Semantic proximity Read ↗

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