Article
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999
Vitaterna M H, Selby C P, Todo T, Niwa H, Thompson C, Fruechte E M, Hitomi K, Thresher R J, Ishikawa T, Miyazaki J, Takahashi J S, Sancar A
Abstract excerpt
Cryptochromes regulate the circadian clock in animals and plants. Humans and mice have two cryptochrome (Cry) genes. A previous study showed that mice lacking the Cry2 gene had reduced sensitivity to acute light induction of the circadian gene mPer1 in the suprachiasmatic nucleus (SCN) and had an...
Topics
- Animals
- Cell Cycle Proteins
- Circadian Rhythm
- Cryptochromes
- Drosophila Proteins
- Eye Proteins
- Flavoproteins
- Gene Expression Regulation
- Genotype
- Mice
- Models, Biological
- Models, Genetic
- Mutagenesis
- Nuclear Proteins