Article
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America - 12 Oct 1999
Vitaterna M H, Selby C P, Todo T, Niwa H, Thompson C, Fruechte E M, Hitomi K, Thresher R J, Ishikawa T, Miyazaki J, Takahashi J S, Sancar A
Abstract excerpt
Cryptochromes regulate the circadian clock in animals and plants. Humans and mice have two cryptochrome (Cry) genes. A previous study showed that mice lacking the Cry2 gene had reduced sensitivity to acute light induction of the circadian gene mPer1 in the suprachiasmatic nucleus (SCN) and had an intrinsic period 1 hr longer than normal. In this study, Cry1(-/-) and Cry1(-/-)Cry2(-/-) mice were generated and...
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