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Article

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.

eLife - 15 Aug 2014

Nangle Shannon N, Rosensweig Clark, Koike Nobuya, Tei Hajime, Takahashi Joseph S, Green Carla B, Zheng Ning

Abstract excerpt

The mammalian circadian clock is driven by a transcriptional-translational feedback loop, which produces robust 24-hr rhythms. Proper oscillation of the clock depends on the complex formation and periodic turnover of the Period and Cryptochrome proteins, which together inhibit their own transcriptional activator complex, CLOCK-BMAL1. We determined the crystal structure of the CRY-binding domain (CBD) of PER2 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25127877
DOI: 10.7554/eLife.03674
PMCID: PMC4157330

Genes

CRY2
BMAL1
CLOCK
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex.PMID 25127877Read ↗

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