Article
Quantitative analyses of cryptochrome-mBMAL1 interactions: mechanistic insights into the transcriptional regulation of the mammalian circadian clock.
The Journal of biological chemistry - 24 Jun 2011
Czarna Anna, Breitkreuz Helena, Mahrenholz Carsten C, Arens Julia, Strauss Holger M, Wolf Eva
Abstract excerpt
The mammalian cryptochromes mCRY1 and mCRY2 act as transcriptional repressors within the 24-h transcription-translational feedback loop of the circadian clock. The C-terminal tail and a preceding predicted coiled coil (CC) of the mCRYs as well as the C-terminal region of the transcription factor mBMAL1 are involved in transcriptional feedback repression. Here we show by fluorescence polarization and isothermal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.