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Article

Human CRY1 variants associate with attention deficit/hyperactivity disorder.

The Journal of clinical investigation - 1 Jul 2020

Onat O Emre, Kars M Ece, Gül Şeref, Bilguvar Kaya, Wu Yiming, Özhan Ayşe, Aydın Cihan, Başak A Nazlı, Trusso M Allegra, Goracci Arianna, Fallerini Chiara, Renieri Alessandra, Casanova Jean-Laurent, Itan Yuval, Atbaşoğlu Cem E, Saka Meram C, Kavaklı İ Halil, Özçelik Tayfun

Abstract excerpt

Attention deficit/hyperactivity disorder (ADHD) is a common and heritable phenotype frequently accompanied by insomnia, anxiety, and depression. Here, using a reverse phenotyping approach, we report heterozygous coding variations in the core circadian clock gene cryptochrome 1 in 15 unrelated multigenerational families with combined ADHD and insomnia. The variants led to functional alterations in the circadian...

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Identifiers

PMID: 32538895
DOI: 10.1172/JCI135500
PMCID: PMC7324179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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