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Article

The Arg-293 of Cryptochrome1 is responsible for the allosteric regulation of CLOCK-CRY1 binding in circadian rhythm.

The Journal of biological chemistry - 11 Dec 2020

Gul Seref, Aydin Cihan, Ozcan Onur, Gurkan Berke, Surme Saliha, Baris Ibrahim, Kavakli Ibrahim Halil

Abstract excerpt

Mammalian circadian clocks are driven by transcription/translation feedback loops composed of positive transcriptional activators (BMAL1 and CLOCK) and negative repressors (CRYPTOCHROMEs (CRYs) and PERIODs (PERs)). CRYs, in complex with PERs, bind to the BMAL1/CLOCK complex and repress E-box-driven transcription of clock-associated genes. There are two individual CRYs, with CRY1 exhibiting higher affinity to the...

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Identifiers

PMID: 33028638
DOI: 10.1074/jbc.RA120.014333
PMCID: PMC7863883

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