Article
Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies.
Nature communications - 7 Jun 2022
Khunsriraksakul Chachrit, McGuire Daniel, Sauteraud Renan, Chen Fang, Yang Lina, Wang Lida, Hughey Jordan, Eckert Scott, Dylan Weissenkampen J, Shenoy Ganesh, Marx Olivia, Carrel Laura, Jiang Bibo, Liu Dajiang J
Abstract excerpt
Transcriptome-wide association studies (TWAS) are popular approaches to test for association between imputed gene expression levels and traits of interest. Here, we propose an integrative method PUMICE (Prediction Using Models Informed by Chromatin conformations and Epigenomics) to integrate 3D genomic and epigenomic data with expression quantitative trait loci (eQTL) to more accurately predict gene expressions....
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