Article

CATaN maps gene regulatory programs that shape genetic risk across complex diseases

2026-07-02

Abstract excerpt

Causal variants of complex traits are enriched at transcription factor (TF) binding sites and are thought to contribute to pathology by disrupting TF activity and thereby causing transcriptome dysregulation. However, existing approaches typically address TF-mediated gene regulatory networks (TF-GRNs) and transcriptomes separately, and methods that jointly leverage both to systematically assess disease heritability...

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Literature Corpus work: 2ba76e0b-ed54-5db2-a5b2-2406def8f1c3
DOI: 10.64898/2026.06.28.735120

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